Pharmaceutical and Healthcare News
Capsicum, of the Solanaceae family, is know to have been cultivated in Central and South America more than 6000 years ago. It was first introduced to Europe in the 13th century originally as a substitute for costly black peppercorn. Today Capsicum is widely used as an API or excipient in both pharmaceutical and personal care sectors as well as in food and beverage applications.
The group of compounds which are responsible for the therapeutic effects of Capsicum are capsaicinoids, which deliver its characteristic warmth and pungency. However, in some cases synthetically derived nonivamide material, an inexpensive alternative to naturally occurring capsaicinoids, is added to Capsicum extracts as a low cost means of increasing the analysed level of capsaicinoids. At higher than permitted levels this addition of nonivamide is non compliant.
Typically Capsicum is used in medicinal creams or patches to treat muscular and arthritic related pain. Ransom Naturals Ltd produce a wide range of Capsicum based extracts to meet the British, European and United States pharmacopeial monographs as well as those standardised for customer specific requirements.
We are one of only a very few European manufacturers of Capsicum related extracts. As regulation continues to tighten we remain ever more focused on maintaining a robust and compliant supply chain. As a result we use only pharmacopeial grade raw material ensuring that the nonivamide content derived from this is always well below the permitted level of not more than 5.0 per cent of the total capsaicinoids content.
- Significant European manufacturer of Capsicum related extracts, oleoresins and tinctures.
- Targeting a variety of pharmacopeia or meeting in house customer specifications
- Regulatory support available for licencing applications
- RNL can work with partners to develop mutual recognition for capsicum related extracts
- In depth finished formulation knowledge across health, personal care and food sectors.
Polygala is a large genus of flowering plants which are commonly known as snakeroots or milkworts and are members of the Polygalaceae family. More than 700 species have been described and the genus shows an intercontinental geographical distribution with representatives native to the Americas, Asia, Africa and Australia. The life forms include shrubs, vines and trees which are characterised by having twisted and conical roots which possess a pungent taste and give off a somewhat woody odour reminiscent of wintergreen (Gaultheria spp).
Guarea rusbyi (Britton) Rusbyi more commonly known as Guapi Bark, Huapi Bark and Grape Bark is a plant native to tropical South and Central America, particularly Bolivia and the eastern Andes. The plant is a member of the Meliaceae family and is an evergreen tree which grows to about 45 m in height. The bark occurs are flat or curved pieces with an outer surface that is fissured and grey brown in colour. It has an astringent taste and is slightly nauseous with a characteristic odour.
Quassia which is also known as Bitter Wood or Jamaican Quassia generally refers to two plants that are members of the Simaroubaceae family, namely Picrasma excelsa (Sw.) Planch. and Quassia amara (L.). P. excelsa is native to the West Indies, more particularly it is found in Cuba, the Dominican Republic, Haiti, Jamaica, Puerto Rico, Saint Vincent and the Grenadines, and Venezuela. On the other hand Q. amara is native to tropical South America. The name quassia lends itself to a former slave from Surinam, Graman Quassia, who in the Eighteenth Century discovered the medicinal properties of the bark of Quassia amara.
Squill (Drimia maritima (L.) )
Squill is a common name for a group of plants that are lily like and are members of the Asparagaceae family. The Squill of commerce comprises two main species namely Drimia maritima (L.) Stearn also known as Urginea maritima and commonly known as maritime squill, sea onion or red squill and Drimia indica (Roxb.) Jessop which is commonly known as Indian squill. Maritime squill is native to coastal areas of the Mediterranean and is found growing wild in France, Portugal, Spain, Italy, Greece, Turkey, Syria, Lebanon, Israel, Algeria and Morocco, at up to 300 m above sea level. It is also found in the Canary Islands and Southern Iran and Iraq. Drimia indica has a distribution from tropical and South Africa, the Indian subcontinent and eastwards to Vietnam.